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Genome-wide TSV / FASTA tables and pre-built mutation × region joins. For REST, live try-it, Python examples, and JSON layer names, open API.

Open API

Annotation layers & methods

Aligned with Summary, Visual, and Browse (colour keys)

These tables are the same evidence you see as tracks and columns in Summary and Browse; colours are aligned across the portal.

Disorder & structure

IUPred / combined disorder MobiDB experimental AlphaFold PDB

Domains, motifs & sites

Pfam ELM PEM core motifs ScanSite MFIB DIBS PhasePro

Variants (merged tables + disease)

TCGA COSMIC cBioPortal ClinVar OMIM

Pathogenicity & downloads

In silico pathogenicity scores (same predictor table as in downloads); somatic mutation layers in TCGA / COSMIC / cBioPortal tabs. For machine-readable field names and programmatic access, see API → Annotation keys.

Bulk downloads

Genome-wide TSV and FASTA tables

Choose a category to see its files and a sample of the real on-disk format. For single-protein tables (full annotation per protein), use the download control on the Summary page, or fetch the same slices via REST on the API page.

One sequence per protein (FASTA) or a wide protein table (TSV) with accessions, gene names, UniProt IDs, transcripts, and other core columns.

No preview: add files under static/download/ on the server.

Proteins.fastaAll protein sequences Proteins.tsvMaster protein table

Exon boundaries and PhastCons-style conservation tracks aligned to protein coordinates.

No preview on this deployment.

Exonborder.tsv Conservation_phastCons.tsv

Low-complexity and repeat annotations (SEG, DUST, TRF).

No preview on this deployment.

ComplexitySeg.tsv ComplexityDust.tsv ComplexityTrf.tsv

Germline polymorphism, disease tracks (OMIM, ClinVar), and dbNSFP-style pathogenicity scores per variant.

No preview on this deployment.

Polymorphism.tsv OMIM_Disease.tsv ClinVar.tsv PathogenicityPredictors.tsvdbNSFP predictors + AlphaMissense (missense)

PDB links and Pfam domain intervals.

No preview on this deployment.

PDB.tsv Disordered_PDB_regions.tsv Pfam.tsv

Disorder (IUPred, Anchor, MobiDB), AIUPred binding propensity vectors, and AlphaFold-related fields.

No preview on this deployment.

IUPred.tsv Anchor.tsv AIUPred_Binding.tsvPer-residue binding scores MobiDB.tsv Alphafold.tsv

Per-position conservation scores.

No preview on this deployment.

Conservation_Scores.tsv

Somatic mutations: TCGA, legacy TCGA (COSMIC-named files), and cBioPortal.

No preview on this deployment.

TCGA_Missense.tsv TCGA_Frameshift.tsv TCGA_Indel.tsv COSMIC_Missense.tsv COSMIC_Frameshift.tsv COSMIC_Indel.tsv CBioportal_Missense.tsv CBioportal_Frameshift.tsv CBioportal_Indel.tsv

ELM motifs, PEM core motifs, ELM switches, and PTM sites (see also disorder / binding tabs for ScanSite and related tracks).

No preview on this deployment.

ELM.tsv ELM_Switches.tsv PTM.tsv

UniProt-derived regions and binding annotations.

No preview on this deployment.

ROI_UniProt.tsv Binding_UniProt.tsv

Interaction resources (DIBS, MFIB) and binding-domain summaries.

No preview on this deployment.

dibs.tsv mfib.tsv binding.tsv

Phase separation calls from PhasePro.

No preview on this deployment.

phasepro.tsv

Significantly mutated regions (iSimpre).

No preview on this deployment.

ISimpre_sig_mutated.tsv

sciencePer-protein and positional data

Download the full annotation table for one protein from the Summary page, or retrieve the same slices via REST from the API page. Positional exports (.txt / .json) are available from the sequence view on Summary.

Mutation × annotation region tables

Tab-separated joins: ClinVar (all clinical significance classes) + somatic cohort variants overlapping MobiDB, ELM, Pfam, MFIB, DIBS, PhasePro

Each file is tab-separated (UTF-8). One row = one variant whose position falls inside one annotated interval (the same variant may appear on multiple rows if it overlaps several regions). Rows from ClinVar include disease names, clinical significance, and identifiers where available. Rows from somatic cohorts include variant class (missense, frameshift, indel), data source, and tumour / sample context fields.

table_chartColumns (all files)

Column	Meaning
`gencode_accession`	GENCODE protein accession (DisCanVis primary key, links to summary URLs).
`gene_name`	HGNC gene symbol where available.
`uniprot_accession`	UniProt accession on the protein record.
`position`	1-based residue position of the variant on the canonical isoform.
`mutation_aa`	Amino-acid change or variant label as stored (e.g. missense notation).
`variant_origin`	clinvar = ClinVar disease rows; somatic = cohort somatic rows (Mutation* tables: TCGA, COSMIC, cBioPortal, …).
`somatic_variant_class`	missense \| frameshift \| indel for somatic rows; empty for ClinVar.
`somatic_database`	Source label from the somatic record; empty for ClinVar.
`clinical_significance`	ClinVar clinical significance (pathogenic, benign, uncertain, etc.); empty for somatic.
`disease_or_cancer_label`	ClinVar disease name or somatic cancer_name / cohort label.
`sample_or_rcv_id`	ClinVar RCV accession(s) or somatic matchable_sample_id.
`db_snp`	dbSNP rs id when present (ClinVar); empty for somatic in this export.
`region_layer`	experimental_disorder \| elm \| pfam \| mfib \| dibs \| phasepro.
`region_start`	Start of the overlapping annotation interval (1-based, inclusive).
`region_end`	End of the overlapping annotation interval (1-based, inclusive).
`region_feature_id`	Stable id where applicable (ELM accession, Pfam hmm_acc, binding region name).
`region_feature_label`	Human-readable type or name (ELM class\|id, Pfam domain name, binding layer tag).
`extra_note`	Somatic phenotype field when set; otherwise empty.

No overlap tables are published on this deployment yet.